As discussed in earlier chapters, medical treatments are not successful in all cases of vitiligo. Tissue grafts have the limitations that large amount of donor skin is needed as there is no cell expansion in these methods. Hence, transplantation of autologous cultured and noncultured melanocytes which involve cell suspension without culture or keratinocyte/melanocyte cocultures are gaining popularity. Transplantation of noncultured melanocytes/keratinocytes suspension has the advantage that cell culture is not needed and that skin harvesting from the donor area, cell separation and application of melanocytes can all be undertaken in a single 3 hour procedure. Indications, contraindications, case selection, preoperative investigations have all been dealt in earlier chapters. This chapter will deal therefore only with specific details of the procedure.