The chapter outlines etiology and pain pathophysiology, general characteristics, clinical characteristics, and diagnosis and treatment of trigeminal neuralgia. The treatment comprises of both medicinal treatment and surgical treatment. The chapter mentions various drugs used and their initial doses with the flow chart mentioning various treatment modalities for the treatment of Trigeminal neuralgia. Surgical treatment describes various forms of modalities such as peripheral nerve injections, peripheral neurectomies, cryotherapy, thermocoagulation, and open procedures etc.