The calcium channel blocker (CCB) is a well established class of drugs for the treatment of cardiovascular diseases (CVD) including hypertension, angina, peripheral vascular disorders and some arrhythmic conditions. Voltage-gated calcium channels are involved in the normal functioning of various types of cells, such as neuronal, neurosecretory and muscle cells. They also play a major role in various pathological processes that occurs in these cells. There are at least two types of calcium channels, L and T. The conventional long-lasting opening calcium channel is termed the L-type channel and is blocked by CCB. T-type channels open transiently at more negative potentials than the L-type.