This chapter discusses history of cardiorenal connectors. It is not rare to see a patient with concomitant heart failure and renal insufficiency and the twin diseases have gained epidemic proportions. Cardiovascular disease is the leading cause of death in patients with end-stage renal disease (ESRD). Heart and kidney act in synchronization to regulate blood pressure, vascular tone, diuresis, natriuresis, intravascular volume, homeostasis, peripheral tissue perfusion and oxygenation. They have endocrine functions with interdependent physiological hormonal actions regulated by arterial natriuretic peptide (ANP) and renin-angiotensin aldosterone system (RAAS).