Hormone replacement therapy (HRT) is the way of replacing or supplementing the declining amount of female sex hormones, namely estrogen and progesterone for treatment of postmenopausal symptoms and prevention of chronic diseases like coronary heart disease (CHD) or osteoporosis during and after menopause, which are attributed to the declining levels of female sex hormones. Progesterone or progestins are added to estrogen in HRT to protect against the risk of hyperplasia and adenocarcinoma of the endometrium as studies have shown that the exogenous estrogens administered alone to non-hysterectomized women significantly increases the risk of endometrial hyperplasia and carcinoma. Prolonged use of this therapeutic modality is associated with a serious concern for disabling or dangerous side effects, including CHD, stroke and cancer. With the available evidence till date, HRT cannot be prescribed for prevention of CHD in menopausal women.