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Chapter-06 History of Statins

BOOK TITLE: Textbook of Cardiology (A Clinical & Historical Perspective)

Author
1. Manchanda SC
2. Makhija A
3. Sharma MK
ISBN
9789350900819
DOI
10.5005/jp/books/12259_6
Edition
1/e
Publishing Year
2013
Pages
10
Author Affiliations
1. Sir Ganga Ram Hospital, New Delhi, India, All India Institute of Medical Sciences (AIIMS); Sir Ganga Ram Hospital, New Delhi, India, AIIMS, New Delhi, India, Sir Ganga Ram Hospital, New Delhi, Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi, India
2. Sir Ganga Ram Hospital, New Delhi, India
3. Sir Ganga Ram Hospital, New Delhi, India
Chapter keywords
history of statins, compactin, pharmacology, stable coronary heart disease, acute coronary syndromes, lipid-lowering drugs

Abstract

This chapter discusses history of statins. The discovery of compactin—initial molecule, mechanism of action, pharmacology, adverse effects and drug interactions, and safety results are described. Current indications of statin, statin trials—primary prevention, statin trials—stable coronary heart disease, statin trials—acute coronary syndromes, utility of statins in special populations, statins in combination with other lipid-lowering drugs, which statin and what dose to start with—Indian scenario, and future directions are discussed.

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