The biomechanical properties of the cornea influence the results and outcomes of various ocular measurements and procedures, and the ability to quantify these properties can enhance our ability to diagnose and manage certain ocular diseases. The ocular response analyzer’s dynamic bidirectional applanation process utilizes three primary components namely a precisely-metered collimated-air-pulse, a pressure transducer, and an electro-optical system. It has the ability to provide a quantitative assessment of corneal biomechanical properties which is valuable in a variety of clinical applications. The chapter discusses in detail about the operation of the ocular response analyzer (ORA), corneal hysteresis (CH), central corneal thickness (CCT), intraocular pressure (IOP), ORA waveform score, ORA in corneal pathologies and refractive surgery, ORA beyond cornea, ORA in glaucoma, and waveform analysis and the keratoconus match index.