In this chapter some common metabolic disorders of cornea are discussed with its ocular manifestations and management. The metabolic disorders of cornea discussed are diabetes mellitus (disorder of glucose metabolism), systemic mucopolysaccharidoses (lysosomal storage disorders), lipidoses (disorders of lipid homeostasis), dyslipoproteinemia (genetic disorders of lipid homeostasis), porphyria (disorder of heme biosynthesis pathway), cystinosis (lysosomal storage disorder), alkaptonuria (deficiency of homogentisate 1,2-dioxygenase), amyloidoses (amyloid deposits in ocular tissues which leads to corneal lesions), serum copper abnormalities and calcium precipitates.