Neonatal corneal opacity may be congenital and is associated with Peters’ anomaly, nonspecific dysgenesis, sclerocornea, congenital hereditary endothelial dystrophy (CHED) and glaucoma which can be treated with infant keratoprosthesis. In such cases it is essential to initiate clinical evaluation and treatment quickly to avoid more severe complications. This chapter discusses in detail about the infant keratoprosthesis with its surgical procedure, outcome, postoperative care and complications. The complications of infant keratoprosthesis include glaucoma, endophthalmitis, retroprosthetic membranes, inflammation, vitreoretinal hemorrhage, retinal tears and detachments. The placement of initial keratoprosthesis associated with lensectomy and pars plana vitrectomy is the procedure of choice and has the best chance of providing useful vision in infants with neonatal corneal opacity.