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Chapter-07 Blood Cholinesterase Level and QTc Interval in Patients with Organophosphate Poisoning

BOOK TITLE: Cardiac Functioning, Disorders, Challenges and Therapies

Author
1. Baydin Ahmet
2. Yardan Turker
3. Erenler Ali Kemal
ISBN
9789350903063
DOI
10.5005/jp/books/11836_7
Edition
1/e
Publishing Year
2013
Pages
18
Author Affiliations
1. Faculty of Medicine, Ondokuz Mayis, University, Samsun, Turkey
2. Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey
3. Ondokuz Mayis, University, Samsun, Turkey
Chapter keywords

Abstract

Organophosphate compounds are predominant group of insecticides used for pest control in many parts of the world. Organophosphates inhibit both true cholinesterase and pseudocholinesterase. Organophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase. In the literature, it has been reported that there have been electrocardiographic abnormalities, including QT interval prolongation in most patients with organophosphate poisoning. In this paper, our aim is emphasize relationship between blood cholinesterase levels and QTc interval after organophosphate intoxication in the light of recent reports.

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