Salicylate intoxication can occur by oral route or topical route in chronic large dose application. In smaller doses, it stimulates respiratory center leading to respiratory alkalosis, and in higher doses it inhibits the Krebs cycle of metabolism thus limiting the production of adenosine triphosphate (ATP) which leads to multisystem failure. Its end effect is severe metabolic acidosis. In laboratory studies basic hematological profile, bleeding, renal, hepatic profiles, electrolytes and arterial blood gases need to be performed. X-ray of the chest may show respiratory signs as pulmonary edema or aspiration. And X-ray of the abdomen may show impaction of tablets in stomach or intestines which may have delayed absorption and prolonged toxicity. The chapter discusses in detail about the cause, diagnosis, and treatment required for salicylate poisoning.