After describing normal anatomy and function of skin, different terminology used in skin disease like hyperkeratosis, macule, papule, erythema, pustule, plaque, patch, ulcer etc. are defined. Common inflammatory lesion like acute dermatitis, eczema, panniculitis, acne vulgaris, some common depigmented lesions like leukoderma, albinism, vitiligo, scaling dermatitis like psoriasis, lichen planus, bullous lesion are also included. Pemphigus, benign tumor squamous papilla, fibroepithelial polyps and pigmented lesion like nevus are described. Premalignant conditions of skin like solar keratosis, xerodema pigmentosa, Bowen disease and malignant skin conditions, eg squamous cell carcinoma, basal cell carcinoma, malignant melanoma, their risk factors, etiopathology, morphology and microscopic features are described also. Benign and malignant adnexal tumors including trichoepithelioma, pilomatrixoma, sebaceous and sweat gland adenoma, eccrine tumors and sebaceous and sweat gland carcinoma are briefly mentioned.