This chapter provides detail description of three-dimensional echocardiographic assessment in pericardial disorders. After reading this chapter you will able to know two-dimensional transthoracic echocardiography in pericardial effusion, three-dimensional transthoracic echocardiography in pericardial effusion, two-dimensional transthoracic echocardiography in constriction, three-dimensional transthoracic echocardiography in constriction, two-dimensional transthoracic echocardiography in pericardial masses, three-dimensional transthoracic echocardiography in pericardial masses. There is table in this chapter which are very well explained for studies with advantages of 3D TTE in evaluating pericardial diseases for better understanding. Conclusion is also mentioned at the end of chapter. Each topic is described with color images. 11 self-explanatory and comprehensive images are included in this chapter. 19 references are given at the end of the chapter to facilitate further reading.