This chapter discusses about the hepatorenal and hepatopulmonary syndromes. Hepatorenal syndrome is functional renal failure with absence of histological changes that occurs in patients with chronic liver disease. It is generally seen in patients with progressive liver failure and ascites. It is a severe complication of end stage liver disease associated with 80–95% mortality at 2 weeks. Acute and chronic are two clinical types of hepatorenal syndrome. Hypovolemia, nephrotoxins, glomerulonephritis, acute tubular necrosis and obstruction are Differential diagnosis of renal failure in cirrhosis. Vasoconstrictors, vasopressin analogs (terlipressin), transjugular intrahepatic portosystemic shunt and liver transplantation are treatment of hepatorenal syndrome. Hepatopulmonary syndrome (HPS) is a disease process with a triad of: liver disease, evidence of widespread intrapulmonary vasodilatation and gas exchange abnormality—increased alveolar arterial oxygen gradient while breathing room air, resulting in hypoxemia. The most common liver disease responsible for HPS is liver cirrhosis. The pathophysiology, diagnosis and treatment of hepatopulmonary syndrome are also discussed in this chapter.