This chapter discusses about nutritional care that involves initial nutrition assessment, pretransplant objectives, post-transplant objectives, therapeutic diet plans, therapeutic lifestyle change, and diet guidelines. Initial nutrition assessment involves reviewing patient history, food allergies or intolerances, diet history for analysis of macronutrients, medications, and anthropometrics. Lifestyle patterns include eating patterns, food preferences, frequency and type of restaurant fare, cultural and religious impact on diet or cuisine, and physical activity. Make patient aware that adherence to the immune suppression Rx regimen is critical, and non-adherence could result in the early and unnecessary loss of an otherwise functioning allograft. Disordered metabolism, diet restrictions, uremia induced anorexia, poly-pharmacy and treatment- related gastrointestinal (GI) distress, losses of nutrients or vitamins during dialysis, and fatigue from the rigors of dialysis treatment need be assessed. Meet increased energy and protein requirements associated with metabolic stress of surgery, wound healing. Provide high fluid intake for adequate hydration with high urine output encountered with good allograft function.