This chapter discusses about deceased donor management, where important legislation defines the donated organ as a gift and contains guidance on who may give, to whom gift may be given, how the gift is given and documented, how the gift may be revoked and immunity from liability in the process. The definition of brain death allows for the recovery of organs with the least amount of ischemic injury, thus promoting the best immediate organ function in the recipient. The clinical presentation of advanced neurologic injury from head trauma, stroke, or anoxia begins with catastrophic brain injury management from the critical care team. The real potential for organ donation is never actually realized due to failures at many points in the transition from patient to donor. Deceased donors treated with corticosteroids expressed significantly reduced tissue and serum proinflammatory cytokines. The physiology of maintaining hemodynamic stability during donor management involves the interaction among the systemic capacitance, the pump and the systemic resistance.