This chapter briefly discusses different De novo post-transplant glomerular diseases. Novo glomerulonephritis is that which occurs in a transplant recipient whose original kidney disease was either not glomerular or was of a different pathological type. De novo post-transplant glomerular diseases have the same pathological features as native diseases of that glomerular type when fully developed or sometimes modified by the immunosuppressive therapy. The most common de novo glomerular diseases are focal segmental glomerulosclerosis (FSGS), collapsing glomerulopathy, membranous glomerulonephritis, membranoproliferative glomerulonephritis (MPGN), thrombotic microangiopathy, antiglomerular basement membrane antibody glomerulonephritis and IgA nephropathy. A definitive diagnosis is made following a systematic examination of the renal biopsy for light, immunofluorescence, and electron microscopy.