Neurological complications have been frequently seen in the early postoperative period. It can have a wide range of etiologies such as imbalances of glucose and electrolytes, sleep deprivation, psychological and pharmacological agents. Its symptoms are agitation, anxiety, coma, hallucinations, motor deficits, etc. Calcineurin inhibitors can produce acute neurotoxicity initially manifested as tremors, hallucinations and speech disturbances. Corticosteroids often produce agitation and insomnia when used in large doses. Critical care myopathy is encountered more frequently in intubated patients and its risk factors include sepsis, the use of high dose steroids and paralytic agents. The first step in management includes evaluation of vital signs, obtaining a proper history inclusive of the patient’s complaints, and performing a physical examination.