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Chapter-55 Renal Transplant Pathology

BOOK TITLE: Kidney & Pancreas Transplantation

Author
1. Troxell Megan L
2. Papadimitriou John C
3. Drachenberg Cinthia B
ISBN
9789351523390
DOI
10.5005/jp/books/12547_56
Edition
1/e
Publishing Year
2015
Pages
44
Author Affiliations
1. Oregon Health & Science School of Medicine, Portland, Oregon, USA
2. University of Maryland Medical Center; University of Maryland School of Medicine, Baltimore, Maryland, USA
3. University of Maryland School of Medicine, Baltimore, Maryland, USA
Chapter keywords
renal cortex, distal tubules, interspersed glomeruli, hematoxylin and eosin (H&E) stain, periodic acid Schiff (PAS), glomerular basement membranes, trichrome stains, renal allograft

Abstract

The normal renal cortex is composed of closely spaced proximal and fewer distal tubules, with interspersed glomeruli. This hematoxylin and eosin (H&E) stain demonstrates the abundant pink granular cytoplasm of proximal tubules, while the few distal tubules are lined by flatter, relatively paler epithelial cells. The periodic acid Schiff (PAS) is helpful in delineating tubular and glomerular basement membranes. The proximal tubules have a luminal brush border that stains weakly magenta with PAS. Trichrome stains are especially important in determining the extent of interstitial fibrosis in a renal allograft. Collagen is stained blue in this Masson’s trichrome, or may be stained green in other trichrome preparations. A normal kidney should have minimal fibrous tissue between tubules in the cortex.

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