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Chapter-72 Islet Cell Transplantation

BOOK TITLE: Kidney & Pancreas Transplantation

Author
1. Molmenti Ernesto P
2. Molmenti Christine Sardo
3. Rilo Horacio
4. Georgiev George
5. Cercone Renee
ISBN
9789351523390
DOI
10.5005/jp/books/12547_73
Edition
1/e
Publishing Year
2015
Pages
10
Author Affiliations
1. Hofstra Northwell School of Medicine, Long Island, New York, USA, North Shore-LIJ Health System, Long Island, New York, USA; Hofstra North Shore–LIJ School of Medicine, Long Island, New York, USA
2. Mailman School of Public Health, Herbert Irving Comprehensive Cancer Center, New York-Presbyterian Columbia University Medical Center, New York, USA
3. Cell Transplant Institute; Arizona Diabetes Center, University of Arizona School of Medicine, Tucson, Arizona, USA
4. Institute for Cellular Transplantation, University of Arizona, Tucson, Arizona, USA
Chapter keywords
chronic pancreatitis, abdominal pain, normoglycemia, pancreatectomy, glycemic excursions, auto islet transplant

Abstract

Chronic pancreatitis is a major medical problem with few effective medical therapies and limited surgical options. In patients with advanced chronic pancreatitis, auto islet transplant is very effective for relieving abdominal pain, improving quality of life and in maintaining endocrine function. Purification of the islets is required to limit the volume infused for allogeneic islet Tx. The purification is accomplished through the use of the Cobe 2991 cell sorter and continuous or discontinuous purification. Once purified the islets are cultured in complete, buffered medium at 37 °C 5% CO2 for a period of several hours to days prior to infusion into the patient. Patients who do not experience normoglycemia require maintenance insulin but do not experience the abrupt and extreme glycemic excursions seen in patients undergoing pancreatectomy alone.

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