This chapter discusses complementary therapy and integrative medicine in sinonasal disease, where complementary and alternative medicine (CAM) is a group of diverse medical and healthcare systems, practices, and products that are not generally considered part of conventional medicine. Integrative medicine (IM) combines conventional medicine and CAM for which there is high-quality evidence of efficacy and safety. Blinding is a large methodological issue in many areas of CAM research. Certain dietary interventions are frequently proposed for patients with sinusitis such as elimination of dairy products, alcohol, processed sugar and wheat products. There is a general trend in the integrative community to attribute chronic rhinosinusitis to an overgrowth of yeast. Anti-inflammatory diets are proposed for a number of conditions thought to be related to chronic inflammation, including atopy. Probiotics are defined as live microbial food ingredients beneficial for health. Radiographic improvement of sinusitis was used as an end point of treatment.