This chapter discusses lasers in facial plastic surgery, where lasers are used to tighten facial skin, treat wrinkles, remove lentigines, improve dyschromia, eliminate facial and unwanted hair. Lasers are used for multiple types of vascular lesions or related problems including telangiectasias, redness, rosacea, vascular malformations, and hemangiomas. Pulsed laser systems delivered high-energy laser light in short pulses, with variable time between pulses. Longer or microsecond pulsed laser systems included the pulsed dye laser (PDL) also known as the flashlamppumped dye laser. The effects of the laser are determined by several factors including the laser wavelength. Three main chromophores for lasers in the skin are water, hemoglobin, and melanin. Cooling techniques can vary depending on the design of the laser. The absorption coefficient of the chromophore also relates to the laser efficiency. Some nonablative lasers affect the vasculature without directly affecting the skin. Melanin is the chromophore in laser hair removal.