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Chapter-118 High Sensitivity C-reactive Protein: The Most Powerful Predictor of Occult Cardiovascular Disease in Patients of Metabolic Syndrome: A Hospital-based Study

BOOK TITLE: CSI: Cardiology Update 2014

Author
1. Chopra HK
2. CK Krishna
3. Sambi RS
4. Aggarwal KK
5. Gupta Pranjali
ISBN
9789351526186
DOI
10.5005/jp/books/12415_119
Edition
1/e
Publishing Year
2015
Pages
9
Author Affiliations
1. Moolchand Medcity Hospital, New Delhi, India, Medanta Moolchand Heart Institute, Moolchand Medcity, New Delhi, India, Medanta Moolchand Heart Institute, Moolchand Medcity; World Wellness Foundation, WHA; AHA, Medanta Moolchand Heart Institute; Moolchand Medcity; World Wellness Foundation, WHA; CSI & IAE; IHJ, JIAE, Medanta Moolchand Heart Institute; Moolchand Medcity; World Wellness Foundation, WHA, Medanta Moolchand Heart Institute, New Delhi, India; CME, Moolchand Medcity, World Wellness, Foundation and WHA; AHA; CSI and IAE; IHJ and JIAE, IAE-2017, CSI-2015; World Wellness Foundation, Country Head, American Heart Association; Medanta Moolchand Heart Institute; Health Committee, SCOPE, Tata Sky FAM Health, New Delhi, India, IAE- 2017, CSI -2015; World Wellness Foundation; American Heart Association; Moolchand Medcity; Physician Governing Body, CME, COP Moolchand Medcity, New Delhi, India, IAE- 2017, CSI -2015; World Wellness Foundation; Physician Governing Body, CME, COP Moolchand Medcity, New Delhi, India
2. National Heart Institute, New Delhi, India, Moolchand Medcity, New Delhi, India
3. National Heart Institute, New Delhi, India
4. Moolchand Medcity; Indian Medical Association; Heart Care Foundation of India, New Delhi, India, Moolchand Medcity, New Delhi, India, Heart Care Foundation of India; Medical Education Moolchand Medcity, New Delhi, India; IJCP Group; Indian Medical Association; Ethical Committee, Delhi Medical Council, New Delhi, India, Board of Medical Education, Moolchand Medcity, New Delhi, India; eMedinewS and IMA News; Indian Medical Association BC Roy Awardee, Moolchand Hospital; Heart Care Foundation of India, Delhi, India, Immediate National Past President,, Heart Care Foundation of India, New Delhi, India, Board of Medical Education, Moolchand Medcity, New Delhi, India; eMedinews and IMA News; Indian Medical Association, BC Roy Awardee
Chapter keywords
Hs-CRP, CVD risk, MetS, metabolic syndrome, interquartile range

Abstract

Hs-CRP can be incorporated as one of the important clinical criteria of severity of occult CVD risk in MetS. The grading of hs-CRP levels in MetS with very high vulnerability of occult CVD occurs in grade III and IV levels. Material and methods includes study population, study design, definition of metabolic syndrome, measurements of serum high-sensitivity C - reactive protein levels and data collection. Statistically, there is a significant difference between two groups with respect to hs-CRP levels. In controls, the hs-CRP levels are of lower order whereas in cases they are of higher order and interquartile range of hs-CRP values in control group had no overlapping values with interquartile range of hs-CRP values in case group. ROC curve analysis for evaluation of hs-CRP levels is a discriminatory function for MetS. Hs-CRP evaluation is the most powerful predictor of occult CVD in patients of MetS leading to high CVD morbidity and mortality and therapeutic intervention may help to improve the outcome.

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