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Chapter-023 Genetics and Coronary Artery Disease—Challenges

BOOK TITLE: CSI: Cardiology Update 2014

Author
1. Kumar Soumitra
2. Bhat Soumen
ISBN
9789351526186
DOI
10.5005/jp/books/12415_24
Edition
1/e
Publishing Year
2015
Pages
6
Author Affiliations
1. Vivekananda Institute of Medical Sciences, Kolkata, India, Fortis Hospitals, Kolkata, West bengal, India, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India, Fortis Hospital, Rabindranath Tagore International Institute of Cardiac Sciences, and Sri Aurobindo Seva Kendra, Kolkata, West Bengal, India
Chapter keywords
Coronary artery diseases, monogenic, hypercholesterolemia, gene therapy, Genetics and Coronary Artery Disease

Abstract

The present chapter provides information on Genetics and Coronary Artery Disease- Challenges. CAD is a multifactorial disease that can be influenced by many different environmental and heritable risk factors. The progress of atherosclerotic disease involves a complex series of events and each event e.g. foam cell formation, SMC recruitment, etc. involves multiple biological pathways and genes. Many studies have concurred that CAD is highly heritable; however, the mechanism underlying the heritable basis have been elusive. CAD risk is monogenic or Mendelian in nature like familial hypercholesterolemia, familial defective ApoB-100. Multiple genes are thought to contribute to CAD, each gene contributing to only a small proportion of the phenotype. The chapter briefly summarizes on genetics and cad with respect to heritability, early findings for coronary artery disease, genome wide association studies and CAD, Role of gene therapy has two parts. First part includes sequencing of one genome and the second one is obviously pharmacogenetics and implications for future and the challenge.

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