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Chapter-038 CoQ10 and CVD Risk Reduction 2014

BOOK TITLE: CSI: Cardiology Update 2014

Author
1. Chopra HK
2. Kumar Adarsh
ISBN
9789351526186
DOI
10.5005/jp/books/12415_39
Edition
1/e
Publishing Year
2015
Pages
3
Author Affiliations
1. Moolchand Medcity Hospital, New Delhi, India, Medanta Moolchand Heart Institute, Moolchand Medcity, New Delhi, India, Medanta Moolchand Heart Institute, Moolchand Medcity; World Wellness Foundation, WHA; AHA, Medanta Moolchand Heart Institute; Moolchand Medcity; World Wellness Foundation, WHA; CSI & IAE; IHJ, JIAE, Medanta Moolchand Heart Institute; Moolchand Medcity; World Wellness Foundation, WHA, Medanta Moolchand Heart Institute, New Delhi, India; CME, Moolchand Medcity, World Wellness, Foundation and WHA; AHA; CSI and IAE; IHJ and JIAE, IAE-2017, CSI-2015; World Wellness Foundation, Country Head, American Heart Association; Medanta Moolchand Heart Institute; Health Committee, SCOPE, Tata Sky FAM Health, New Delhi, India, IAE- 2017, CSI -2015; World Wellness Foundation; American Heart Association; Moolchand Medcity; Physician Governing Body, CME, COP Moolchand Medcity, New Delhi, India, IAE- 2017, CSI -2015; World Wellness Foundation; Physician Governing Body, CME, COP Moolchand Medcity, New Delhi, India
2. All India Institute of Medical Sciences, New Delhi, India
Chapter keywords
Coenzyme Q10, CoQ10, ubiquinone, 2, 3-dimethoxy-5-methyl-6-decaprenyl-1, 4-benzoquinone, antioxidant, heart failure, ventricular dysfunction, angina, coronary artery disease, CAD, cardiac arrhythmias, ventricular fibrillation, ventricular tachycardia, cardiovascular surgery

Abstract

Coenzyme Q10 (CoQ10) or ubiquinone (2, 3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone) is a component of the electron transport chain present in mitochondria. It provides energy by participating in the production of ATP and is also a natural antioxidant. A reduced serum level and myocardial tissue content of CoQ10 has been observed in patients with heart failure (HF), with a correlation between CoQ10 deficiency and the severity of symptoms and the degree of left ventricular dysfunction. It has been shown to improve survival in chronic HF and the results of the Q-SYMBIO Trial support its use as part of the maintenance therapy in all chronic HF patients. CoQ10 has been shown to improve exercise tolerance and angina as well as reduce the risk of coronary artery disease (CAD). It can also be used as an adjunct hypertensive and has been shown to be effective in hypertension in diabetes. It may also be helpful in reducing the occurrence of cardiac arrhythmias like ventricular fibrillation (VF)/ventricular tachycardia (VT). CoQ10 usage in cardiovascular surgery resulted in better postoperative results.

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