Bioresorbable scaffold is a potential device used for the treatment of coronary artery disease, with providing temporary vessel scaffold, then gradually being resorbed free of any caging eventually restoring the vessel wall physiology and vasomotion. In this chapter some contemporary bioresorbable scaffolds and ongoing clinical trials are discussed i.e. Igaki-Tamai bioresorbable scaffold, absorb bioresorbable vascular scaffold, drug-eluting absorbable metal scaffold, DESolve bioresorbable coronary scaffold and other bioresorbable scaffolds. Bioresorbable scaffold for acute myocardial infarction and bioresorbable scaffold for complex lesions are also discussed. The clinical outcomes regarding the safety and efficacy of bioresorbable scaffold following BRSs implantation appear promising in the treatment of patients with either de novo lesions or AMI.