More women die every year of cardiovascular disease (CVD) than of breast or uterine cancer. This chapter summarizes epidemiology, etiology, prognosis and management of heart failure (HF) in women. The causes of HF in women are hypertensive, valvular disease, peripartum cardiomyopathy, have preserved systolic function, and have less coronary artery disease. The pharmacologic interventions in management of women with HF include angiotensin converting enzyme inhibitor, angiotensin receptor blockers, beta-blockers and digoxin. The nonpharmacologic interventions in management of women with HF include surgical therapies, bypass surgery, mitral valve repair, left ventricular assist device placement and cardiac transplantation.