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Chapter-102 Bioactives in Obesity

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Joshi Shilpa S
2. Joshi Shashank R
ISBN
9789351526476
DOI
10.5005/jp/books/12535_127
Edition
2/e
Publishing Year
2015
Pages
5
Author Affiliations
1. Mumbai Diet and Health Centre, Mumbai, Maharashtra, India
2. Grant Medical College and Sir JJ Group, Hospital, Consultant Endocrinologist, Lilavati and Bhatia Hospital, Mumbai, Maharashtra, India, Seth G.S. Medical College and K.E.M. Hospital Mumbai, Maharashtra, India, Bhatia Hospital, Joshi Clinic, Lilavati Hospital and Research Centre, A-791, Bandra Reclamation, Bandra (W), Mumbai, Maharashtra, India, Bhatia Hospital, Joshi Clinic, Lilavati Hospital and Research Centre, A-791, Bandra, Reclamation, Bandra (W), Mumbai, Maharashtra, India, S. L. Raheja Hospital, Bhatia Hospital, and Sir H. N. Hospital, Mumbai, Seth GS Medical College, Mumbai, Maharashtra, India, Lilavati and Bhatia Hospital, Mumbai, Maharashtra, India; Grant Medical College and Sir Jj Group of Hospitals, Mumbai 400 008, Maharashtra, India, Joshi Clinic, Lilavati and Bhatia Hospital; Association of Physicians of India (API), Mumbai, Maharashtra, India, Joshi Clinic, Lilavati and Bhatia Hospital; Association of Physicians of India (API), Indian Academy of Diabetes, Joshi Clinic, Mumbai, Maharashtra, Indi
Chapter keywords
Bioactives, pharmacotherapy, obesity, piperine, curcumin, resveratrol

Abstract

The prevalence of obesity has been increasing worldwide, which has also led to a dramatic increase in the risk of cardiovascular diseases, type 2 diabetes, and Metabolic Syndrome. Complex interactions among neuroanatomical, genetic, endocrinological, pathophysiological, nutritional, physical, psychological, and social–environmental factors are the reasons of energy balance in humans. Pharmacotherapy to tackle obesity is required as adjunctive support to diet, exercise, and lifestyle modification. Human and animal studies provide evidence to support the insistence that the use of dietary bioactive compounds can increase thermogenesis and energy expenditure (EE), providing additional benefits in preventing obesity. Bioactives are essential and nonessential compounds that occur in nature as part of our food chain that has an effect on our human health. The role of bioactives is to reduce adipose tissue mass and adipocyte size, which lead to improvements in insulin sensitivity. Some dietary bioactives are polyphenols, curcumin, tea, and resveratrol. Lifestyle modification is the mainstay in obesity management. Diet, exercise, and positive attitude form pillars of weight control.

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