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Chapter-014a Insulin Therapy: Pharmacology of Insulin

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Kalra Sanjay
2. Chadha Manoj
3. Gupta Yashdeep
ISBN
9789351526476
DOI
10.5005/jp/books/12535_16
Edition
2/e
Publishing Year
2015
Pages
5
Author Affiliations
1. Bharti Hospital, Karnal, Haryana, India, Bharti Hospital and B.R.I.D.E., Karnal 132 001, Haryana, India, Bharti Hospital and BRIDE Karnal; Indian J Endocrinology Metabolism, Bharti Hospital, Karnal, Haryana, India, Bharti Hospital, Karnal-132001, Haryana, India, Indian J Endocrinology and Metabolism; J of Social Health in Diabetes (JoSH Diabetes), Bharti Hospital and BRIDE, Karnal, Haryana, India, Bharti Hospital and BRIDE, Karnal, Haryana, India
2. P.D. Hinduja National Hospital, Mumbai, B.Y.L. Nair Hospital and T.N. Medical College, Mumbai, Maharashtra, India, PD Hinduja Hospital and Research Centre, Mumbai, Maharashtra, India, PD Hinduja Hospital, Mumbai, Maharashtra, India, PD Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India
3. Government Medical College and Hospital, Sector 32, Chandigarh-160030, India, Government Medical College and Hospital, Chandigarh, India, All India Institute of Medical Sciences, New Delhi, India, Department of Endocrinology and Metabolism
Chapter keywords
Insulin therapy, pancreatic islet b cells, precursor yeast recombinant, tyrosine kinase activity, insulin glargine, Neutral protamine hagedorn

Abstract

Insulin is an important hormone which is a focus of attention of pharmacological researchers in the field of diabetes. Since 1923, insulin was available for relatively widespread treatment of diabetes. Insulin is produced by pancreatic islet b cells and the average amount secreted per day in a normal human is about 40 U (287 nmol). Insulin is used to trigger tyrosine kinase activity of the β subunits and this is the key reaction which helps insulin to put forth its biologic effects. Insulin molecule differs from species to species by its composition but the biologic activity of particular insulin is not affected by this difference. Mostly all insulin is injected subcutaneously and intravenous is the route of administration for regular human insulin and the rapid acting analogs. This chapter gives an overview of insulin which can be used for further understanding of insulin therapeutics.

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