Chapter-002 Diabesity

BOOK TITLE: ESI Manual of Clinical Endocrinology

1. Sahay Rakesh Kumar
2. Nagesh V Sri
3. Modi KD
Publishing Year
Author Affiliations
1. Gandhi Medical College and Hospital, Secunderabad, Andhra Pradesh, India, Osmania Medical College, Hyderabad, Andhra Pradesh, India
2. Care Hospitals, Hyderabad, Andhra Pradesh, India, CARE Hospital, Hyderabad, Telangana, India, Care Hospital, Banjara Hills, Hyderabad, Andhra Pradesh, India
3. Care Hospital, Hyderabad, Andhra Pradesh, India, Modi’s Clinic, Besides Siddiqua Function Hall, Asif Nagar, Mehadipatnam, Hyderabad, Andhra Pradesh, India; Medwin Hospital, Hyderabad, India; Hyderabad Society of Endocrinology; Endocrine Society of India
Chapter keywords
Diabesity, hypertension, adiposity, insulin, phenteremine, metformin, ileal transposition, sibutramine


Diabesity is a portmanteau word that aptly refers to the strong link between type 2 diabetes and obesity. It is a syndrome complex that comprises of central obesity, hyperglycemia, hypertension, hyperlipidemia, and high low-density lipoprotein, systemic inflammation and the prothrombotic state. The risk of diabetes in obese people is 6–9.5%, and > 50% of diabetic patients is overweight or obese. Pathophysiology, anthropometric indices, treatment, exercise and behavioral therapy pharmacotherapy, bariatric surgery, ileal transposition, pediatric obesity, polycystic ovarian syndrome and prevention are well exemplified. Knowledge about this disorder and willingness to treat, both on the part of the patient and physician, is still lacking. The insidiousness nature of its development, lack of potent therapeutic regimens, protean manifestations and adoption of a westernized lifestyle ill suited to the Indian physique have all contrived to place India on the pedestal of worldwide diabesity. Positive changes within the society, strong political and personal will, school and workplace behavior modification, endorsement of a healthy lifestyle and a holistic approach to treatment is needed to combat this problem.

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