EXPORT CITATION

Chapter-024 Nonalcoholic Fatty Liver Disease and Diabetes

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Seshadri Krishna G
ISBN
9789351526476
DOI
10.5005/jp/books/12535_31
Edition
2/e
Publishing Year
2015
Pages
9
Author Affiliations
1. Sri Ramachandra University; Fortis Malar Hospital, Chennai, Tamil Nadu, India, Sri Ramachandra University, Chennai, Tamil Nadu, India
Chapter keywords
Nonalcoholic fatty liver disease, hepatic steatosis, AMP kinase, magnetic resonance spectroscopy, transient elastography, cytokeratin 18, metformin

Abstract

Nonalcoholic fatty liver disease (NAFLD) occurs due to fat accumulation in the liver in the absence of excess alcohol consumption and it leads to hepatic steatosis. It is the most common chronic liver disease in the world and their prevalence rate increases with age. It has been reported that 63–87% of patients with type 2 diabetes have NAFLD with fibrosis. Nonalcoholic steatohepatitis (NASH) is associated with increased fat accumulation, liver injury and inflammation due to oxidative stress. Fat accumulation in liver is the strongest predictor of insulin stimulated myocardial glucose uptake and it also inhibits insulin signaling in hepatocytes. Magnetic resonance spectroscopy is the most sensitive noninvasive method for the diagnosis of NAFLD. Circulating cytokeratin 18 (CY18) fragments act as a marker of apoptosis which has high specificity for NASH and its progression. Metformin is used as a beneficial drug to minimize the increased risk of hepatocellular carcinoma. However, lifestyle changes are the basis to prevent the progression of NAFLD.

Related Books

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved

Powered by MPS ScholarStor