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Chapter-031c Testosterone and Diabetes Emerging Links

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Ganie Mohd Ashraf
2. Nisar Sobia
3. Kuchay Mohd Shafi
ISBN
9789351526476
DOI
10.5005/jp/books/12535_40
Edition
2/e
Publishing Year
2015
Pages
5
Author Affiliations
1. All India Institute of Medical Sciences, New Delhi, India, Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India
2. All India Institute of Medical Sciences, New Delhi, India
3. Medanta-The Medicity, Gurgaon, NCR Delhi, India
Chapter keywords
Testosterone, dyslipidemia, insulin resistance, type 2 diabetes, androgen deprivation therapy, tumor necrosis factor-alpha, Leydig cell

Abstract

This chapter discusses the role of androgen (testosterone) deficiency and its emerging links with type 2 diabetes (T2DM). The main components of the metabolic syndrome are visceral obesity, insulin resistance (IR), glucose intolerance, raised blood pressure and dyslipidemia. The Massachusetts male aging study reveals that low levels of testosterone and low sex hormone-binding globulin are associated with the development of IR and T2DM. Hypogonadism is also a risk factor for the development of elevated insulin and glucose levels compared with obesity. Androgen deprivation therapy (ADT) results in increases of IR, alters glycemic control and may contribute to development of T2DM. Testosterone treatment in insulin-dependent patients reduces their insulin dosages and also helps in maintaining glycemic control. The apoptotic damage induced by streptozotocin in castrated animals can be treated by testosterone replacement. The exact mechanism of testosterone in IR and T2DM is not clearly known.

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