Chapter-033 Metabolic Syndrome and the Gut Flora

BOOK TITLE: ESI Manual of Clinical Endocrinology

1. Sridhar GR
Publishing Year
Author Affiliations
1. Endocrine and Diabetes Centre, Vishakhapatnam, Endocrine and Diabetes Center, Krishnanagar, Vishakhapatnam, India, Endocrine and Diabetes Centre, Visakhapatnam, India, Endocrine and Diabetes Centre, Krishnanagar Visakhapatnam, Andhra Pradesh, India, Endocrine and Diabetes Centre, Visakhapatnam, Andhra Pradesh, India, Endocrine and Diabetes Centre, Visakhapatnam, Andhra Pradesh India
Chapter keywords
Microbiome, quorum sensing, Metabolic Syndrome, gut microbiota, probiotics, fecal transplantation, hyperinsulinemic euglycemic clamp


Microbes are often associated with disease and poor hygiene and having a close interaction with human that could make the difference between health and disease. Obesity and Metabolic syndrome are results from an impaired homeostasis of gut microbes. Bacterial cells outnumber human cells where microbiome has 100 times more genes than the human genome. Quorum sensing is where microbes interact with one another, singly and as colonies. When interaction takes place is by means of gut microbiota leading to an inflammatory response, which in turn results in insulin resistance. Identification of the bacterial species largely depends on whole genome sequencing. Microbiota modulates and regulates host energy intake, expenditure, and storage by various biochemical actions and it is studied in both human and animals. The Condition such as metabolic syndrome was subjected to treatment by fecal transplantation by human studies which hypothesized to improve insulin sensitivity. This chapter also discusses other beneficial microorganisms, such as probiotics and probiotics.

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