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Chapter-039 Hypothyroidism

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Bajaj Sarita
2. Singh SK
3. Patel Vivek H
ISBN
9789351526476
DOI
10.5005/jp/books/12535_48
Edition
2/e
Publishing Year
2015
Pages
8
Author Affiliations
1. MLN Medical College, Allahabad, India, MLN Medical College, Allahabad, Uttar Pradesh, India, Moti Lal Nehru Medical College, Allahabad 211 001, UP, India, South Asian Federation of Endocrine Societies (SAFES); Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India, Moti Lal Nehru Medical College, Allahabad, UP, India, MLN Medical College, Allahabad (UP), India, Motilal Nehru Medical College, Allahabad, Uttar Pradesh, India
2. Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Institute of Medical Sciences, Banaras Hindu University, Varanasi (UP), India, Institute of Medical Sciences, Varanasi, Uttar Pradesh, India, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
3. Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Chapter keywords
Hypothyroidism, glycosaminoglycans, creatine phosphokinase, paresthesia, myxedema coma, external beam radiotherapy

Abstract

Hypothyroidism is most commonly encountered disorder among all clinical disorders of thyroid gland. It is characterized by deficient production and secretion of thyroid hormones resulting in low circulating levels and reduced action at cellular level. Symptoms associated with this disease are dependent on age, rate of development of hypothyroidism, degree of hypothyroidism and presence or absence of other comorbidities. It is associated with several clinical manifestations such as musculoskeleton system manifestation, GI system, reproductive system, hematopoeitic system, nervous system, cardiovascular system and respiratory system manifestations. Laboratory diagnosis depends on the measurement of TSH and free T4. The primary benefit of screening is the detection of hypothyroidism before occurrence of symptoms and it is suggested for patients with increased risk of hypothyroidism such as presence of goiter, family history of thyroid disease and so on. Levothyroxine (LT4) is the treatment of choice for hypothyroidism and this chapter discusses in detail about this treatment with related information on initiation, monitoring, response and adverse effects.

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