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Chapter-040 Thyrotoxicosis

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Sahay Rakesh Kumar
2. Bantwal Ganapathi
ISBN
9789351526476
DOI
10.5005/jp/books/12535_49
Edition
2/e
Publishing Year
2015
Pages
8
Author Affiliations
1. Gandhi Medical College and Hospital, Secunderabad, Andhra Pradesh, India, Osmania Medical College, Hyderabad, Andhra Pradesh, India
2. St John’s Medical College and Hospital, Bengaluru, Karnataka, India, St. Johns Medical College Hospital, Bangalore, Karnataka, India, St. John’s Medical College and Hospital, Bengaluru, Karnataka, India, St. Johns Medical College, Bengaluru, Karnataka, India
Chapter keywords
Toxic multinodular goiter, toxic adenoma, thyroiditis, hyperdefecation, leukocytosis, thionamides, thyroid sonography

Abstract

Thyrotoxicosis is a clinical syndrome of hypermetabolism and hyperactivity that results from excessive quantities of the thyroid hormones. It ranges in severity from subclinical hyperthyroidism to life threatening thyroid storm. The most common cause of thyrotoxicosis is Graves’ disease, followed by toxic multinodular goiter (TMNG), solitary toxic adenoma and thyroiditis. Graves’ disease, toxic multinodular goiter, toxic adenoma, thyroiditis are associated with thyrotoxicosis. It may also cause other laboratory abnormalities such as hyperglycemia, hypercalcemia, elevated alkaline phosphatase, leukocytosis, and elevated liver enzymes. Thyroid nuclear imaging studies and anatomic studies like thyroid ultrasound are different imaging modalities may assist in the determination of the etiology of this disease. Radioactive iodine uptake, scanning and thyroid sonography are very useful tools in the diagnostic evaluation methods. The thionamides and beta-adrenergic blocking drugs are used as treatment and are useful adjuncts to the management of thyrotoxicosis. Apart from these, this chapter also discusses about different management strategies.

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