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Chapter-047b Drugs and Thyroid

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Kalra Sanjay
2. Baruah Manash P
3. Jain Suyog Subhash
ISBN
9789351526476
DOI
10.5005/jp/books/12535_57
Edition
2/e
Publishing Year
2015
Pages
4
Author Affiliations
1. Bharti Hospital, Karnal, Haryana, India, Bharti Hospital and B.R.I.D.E., Karnal 132 001, Haryana, India, Bharti Hospital and BRIDE Karnal; Indian J Endocrinology Metabolism, Bharti Hospital, Karnal, Haryana, India, Bharti Hospital, Karnal-132001, Haryana, India, Indian J Endocrinology and Metabolism; J of Social Health in Diabetes (JoSH Diabetes), Bharti Hospital and BRIDE, Karnal, Haryana, India, Bharti Hospital and BRIDE, Karnal, Haryana, India
2. Excelcare Hospital, Guwahati, Assam, India, Excel Center, Guwahati, Assam, India, Specialization—Clinical Endocrinology, Excelcare Hospitals (P) Ltd., Guwahati, Assam, India, Excel Center (A Unit of Excelcare Hospitals), Guwahati, Assam, India, Excel Care Hospital, Guwahati, Assam, India
3. Government Medical College, Miraj, Maharashtra, India
Chapter keywords
Thyroid gland, thyroid-stimulating hormone, thyroid-binding globulin, autoimmunity, levothyroxine

Abstract

This chapter has detail of the various mechanisms and effects of drugs on the thyroid gland. Iatrogenic thyroid disease is often due to overprescription of the antithyroid drugs such as carbimazole, methimazole, and propylthiouracil. Mechanism of action depends upon the effect of drugs which affects the thyroid function at various levels. Drugs affect thyroid-stimulating hormone, thyroid hormone secretion, TBG concentration etc. Various drugs interfere with the metabolic pathways of thyroid hormone and autoimmunity etc. The drug-induced effects described so far are mediated through the thyroid physiology. A reduction in absorption may necessitate an increase in thyroxine requirements and may decrease serum T4, while increasing serum TSH concentrations.

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