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Chapter-005 Gestational Diabetes Mellitus

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Sridhar GR
2. Nagamani G
ISBN
9789351526476
DOI
10.5005/jp/books/12535_6
Edition
2/e
Publishing Year
2015
Pages
7
Author Affiliations
1. Endocrine and Diabetes Centre, Vishakhapatnam, Endocrine and Diabetes Center, Krishnanagar, Vishakhapatnam, India, Endocrine and Diabetes Centre, Visakhapatnam, India, Endocrine and Diabetes Centre, Krishnanagar Visakhapatnam, Andhra Pradesh, India, Endocrine and Diabetes Centre, Visakhapatnam, Andhra Pradesh, India, Endocrine and Diabetes Centre, Visakhapatnam, Andhra Pradesh India
2. Andhra Medical College, Visakhapatnam, Andhra Pradesh, India
Chapter keywords
Ketoacidosis, cortisol, leptin, adiponectin, euglycemia, hyperbilirubinemia, dysglycemia, microalbuminuria

Abstract

Gestational diabetes mellitus (GDM) has been described as the identification of “glucose intolerance with its onset during pregnancy”. The characterization only refers to when glucose intolerance was first identified viz. during pregnancy. Its prevalence, glucose regulation in pregnancy, rationale of diagnosis of GDM, diagnosis of diabetes in pregnancy and reassurance to the pregnant woman with dysglycemia are well explained. Mechanisms of nutritional programming and epigenetic mechanisms are explained under the biological rationale for euglycemia in pregnancy. Extensive biochemical, clinical, and epidemiological evidence is available to assure euglycemia during pregnancy. Relevant obstetric management of fetal well-being must be ensured, with trimester-wise ultrasound monitor, fetal echo is a must at 24 weeks to rule out cardiac defects and fetal biophysical profile in the late pregnancy.

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