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Chapter-051 Disorders of Growth Hormone Excess

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Suresh V
2. Reddy Amaresh P
ISBN
9789351526476
DOI
10.5005/jp/books/12535_66
Edition
2/e
Publishing Year
2015
Pages
8
Author Affiliations
1. Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
2. Narayana Medical institutions, Nellore, Andhra Pradesh, India
Chapter keywords
Growth Hormone Excess, somatotrophic, homocystinuria, Psychiatric morbidity, Genitourinary, thyrotropin-releasing hormone, acromegaly

Abstract

Growth hormone is the principal hormone responsible for growth during childhood and adolescence. Growth hormone excess states are relatively rare disorders having a prevalence of 38–69 cases per million population. Growth hormone excess is caused by GH-secreting pituitary adenomas that are classified as pure somatotrophic, mammosomatotrophic. Clinical features of growth hormone excess are related either to its growth promoting properties by IGF-1 or its metabolic effects. Clinical presentation of growth hormone excess in Indians is also described here. Diagnosis of growth hormone excess is possible only when the condition is clinically suspected, because of the slow progression of changes. Radiographic changes are helpful to study the changes. Management of growth hormone excess includes radiotherapy, medical therapy and surgery. In addition prognosis of GH, cancer risk in Acromegaly and post-treatment follow-up also described here.

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