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Chapter-070 Primary Hyperparathyroidism: An Indian Perspective

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Mithal Ambrish
2. Bhadada Sanjay Kumar
ISBN
9789351526476
DOI
10.5005/jp/books/12535_86
Edition
2/e
Publishing Year
2015
Pages
9
Author Affiliations
1. Medanta – The Medicity, Gurgaon, Haryana, India, Medanta Medicity, Gurgaon, Haryana, India, Medanta - The Medicity, Gurgaon 122 001, Haryana, India, Medanta, The Medicity, Gurgaon, Haryana, India, Medanta–The Medicity, Gurgaon, Haryana, India, Medanta the Medicity, Gurgaon, Haryana, India
2. PGIMER Chandigarh, India, (ESICON 2014); PGIMER, Chandigarh, India
Chapter keywords
Calcium-sensing receptor, cell cycle regulator, cyclin D1, 2D gel electrophoresis, mass spectrometry, conventional surgery

Abstract

Primary hyperparathyroidism (PHPT) is a common endocrine disorder. It is caused by hypercalcemia and more commonly occur in females. It reduces urinary calcium excretion and increased phosphate excretion. Calcium homeostasis molecules like calcium-sensing receptor, and vitamin D receptor (VDR), cell cycle regulator, cyclin D1, 2D gel electrophoresis and mass spectrometry-based proteomics approach are used in the pathogenesis of PHPT. Presenting manifestation, skeletal manifestation, renal manifestation, neuromuscular manifestations, gastrointestinal manifestation, hematological manifestations and miscellaneous manifestation are briefly discussed in this chapter. Hydration, increased salt intake, mild and forced dieresis and bisphosphonates are used for treatment purpose. Surgical treatment (conventional surgery) is used for the treatment of symptomatic primary hyperparathyroidism. The management of asymptomatic primary hyperparathyroidism is also discussed in this chapter.

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