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Chapter-072b Vitamin D Toxicity

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Mithal Ambrish
2. Kaur Parjeet
3. Mishra Sunil Kumar
ISBN
9789351526476
DOI
10.5005/jp/books/12535_89
Edition
2/e
Publishing Year
2015
Pages
4
Author Affiliations
1. Medanta Medicity, Gurgaon, Haryana, India, Max Healthcare, Saket, New Delhi, India, Medanta–The Medicity, Gurugram, Haryana, India, Division of Max Healthcare Hospital, Saket, New Delhi, India, Medanta Hospital, Gurugram, Haryana, India, Medanta - The Medicity, Gurugram, Haryana, India, Medanta the Medicity, Gurgaon, Haryana, India, Medanta–The Medicity, Gurgaon, Haryana, India, Medanta, The Medicity, Gurgaon, Haryana, India, Medanta - The Medicity, Gurgaon 122 001, Haryana, India, Medanta – The Medicity, Gurgaon, Haryana, India
2. Medanta, The Medicity, Gurgaon, Haryana, India, Medanta Medicity, Gurgaon, Haryana, India, Medanta - The Medicity, Gurgaon, Haryana, India, Medanta - The Medicity Hospital, Gurugram, Haryana, India, Medanta - The Medicity, Gurugram, Haryana, India
3. Medanta, the Medicity, Gurgaon, Haryana, India, Medanta—The Medicity, Gurugram, Haryana, India
Chapter keywords
Hypercalcemia, iPTH, vitamin D receptor, vitamin D supplements, DBP-binding capacity

Abstract

Vitamin D plays a significant role in the maintenance of health. This chapter deals with vitamin D toxicity, presentation, risk factors, management, and prevention. Low vitamin D levels have been linked with many skeletal and nonskeletal disorders. However, too much vitamin D can be as harmful as too little. Vitamin D cases presented with hypercalcemia. It is a preventable entity. The etiology of vitamin D toxicity can result from excess intake of vitamin D (oral or parenteral) or its analogs and improper use of pharmaceutical preparations of vitamin D is the most frequent cause of vitamin D toxicity. The toxic dose of vitamin D has not been established. Several theories have been hypothesized to explain the mechanism of vitamin D toxicity and all involve activation of vitamin D receptor. Finding of raised 25(OH) D level and suppressed iPTH in the presence of hypercalcemia verify the diagnosis of vitamin D toxicity. The use of vitamin D supplements, avoidance of parenteral preparation of vitamin D unless there is evidence of malabsorption can prevent this condition.

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