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Chapter-073c Treatment of Osteoporosis

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Mithal Ambrish
2. Bansal Beena
ISBN
9789351526476
DOI
10.5005/jp/books/12535_92
Edition
2/e
Publishing Year
2015
Pages
6
Author Affiliations
1. Medanta – The Medicity, Gurgaon, Haryana, India, Medanta Medicity, Gurgaon, Haryana, India, Medanta - The Medicity, Gurgaon 122 001, Haryana, India, Medanta, The Medicity, Gurgaon, Haryana, India, Medanta–The Medicity, Gurgaon, Haryana, India, Medanta the Medicity, Gurgaon, Haryana, India
2. Medanta – The Medicity, Gurgaon, Haryana, India, Medanta - The Medicity, Gurgaon 122 001, Haryana, India, Medanta–The Medicity, Gurgaon, Haryana, India, Medanta, the Medicity, Gurgaon, Haryana, India, Medanta - The Medicity, Gurgaon, Haryana, India
Chapter keywords
Bone density, tamoxifen, raloxifene, calcitonin, teriparatide, strontium ranelate, denosumab

Abstract

Osteoporosis is a disease, caused by a low bone density. There are several nonpharmacological measures (good nutrition, risk factor reduction, physical activity and hip protectors) that are useful in managing osteoporosis. Antiresorptive and anabolic drugs are used for a treatment of osteoporosis. Bisphosphonates are also used for prevent the disease. Estrogen deficiency causes the increase in cytokines, which in turn increases recruitment and activation of osteoblasts. Using estrogen plus progestin as hormone replacement therapy reduces the risk of fractures at all sites including hip. SERMS (Selective estrogen receptor modulators) act on estrogen receptors. It shows the agonistic effect on some target tissues and antagonistic on others. Tamoxifen and raloxifene are two most popular drugs that come under this category. Calcitonin, Teriparatide, Strontium and Denosumab drugs are also used for the treatment of postmenopausal osteoporosis. Odanacatib and sclerostin inhibitor are used in future therapies.

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