Chapter-079 Polycystic Ovary Syndrome

BOOK TITLE: ESI Manual of Clinical Endocrinology

1. Ganie Mohd Ashraf
2. Kuchay Mohd Shafi
3. Douhath Syed
4. Pandita KK
Publishing Year
Author Affiliations
1. All India Institute of Medical Sciences, New Delhi, India, Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India
2. Medanta-The Medicity, Gurgaon, NCR Delhi, India
3. Sheri-Kashmir Institute of Medical Sciences, Srinagar, India
4. Acharya Sidra Medical College, Jammu, India
Chapter keywords
Polycystic ovary syndrome, endocrine disorder, pathophysiological, ovarian dysfunction, oligomenorrhea, pharmacotherapy, laparoscopic ovarian diathermy


Polycystic ovary syndrome (PCOS) is the most general endocrine disorder in a women reproductive system. The correct pathophysiology of PCOS is difficult and remains largely indistinct. Insulin resistance is a pathophysiological contributor in around 50–80% of women with PCOS. Obesity and excess weight are the main chronic diseases. The mass of PCOS women have ovarian dysfunction with 70% to 80% of women with PCOS presenting with oligomenorrhea or amenorrhea. Endocrine disruptor chemicals like testosterone may be acting during the critical time interval of fetal development. Lifestyle intensely affects the phenotypic expression of PCOS. Women with PCOS also grow abnormal glucose metabolism at a younger age. The criteria for purposes of diagnosis have been varying from time to time. Pharmacotherapy includes many agents that may be valuable in addressing the individual components. Laparoscopic ovarian diathermy or laser drilling has been used for surgical treatment of polycystic ovary syndrome. The treatment is no longer symptomatic, and attempts are to invalidate the basic pathogenic mechanism such as insulin resistance and androgen excess.

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