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Chapter-080 Hyperandrogenism Other than PCOS

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Kalra Pramila
ISBN
9789351526476
DOI
10.5005/jp/books/12535_99
Edition
2/e
Publishing Year
2015
Pages
13
Author Affiliations
1. MS Ramaiah Medical College, Bengaluru, India, MS Ramaiah Medical College, Bengaluru, Karnataka, India
Chapter keywords
Hyperandrogenism, acanthosis nigricans, insulin resistance syndrome, idiopathic hyperandrogenemia, follicle-stimulating hormone, Cushing’s syndrome, oral contraceptives pills

Abstract

Hyperandrogenism in females is a condition characterized by unnecessary secretion of androgens by the adrenal cortex or ovaries. Hyperandrogenemia, acanthosis nigricans and insulin resistance syndrome is a multisystem disorder in women. The term idiopathic hyperandrogenemia is used for those groups of patients who may exhibit follicle-stimulating hormone. Cushing’s syndrome occurs due to an extreme production of cortisol. Ovarian hyperthecosis is due to the demarcation of ovarian interstitial cells into the steroidogenically active luteinized stromal cells. The pilosebaceous unit includes sebaceous gland and a pilary component that gives rise to the hair shaft. The major serum androgens in normal cycling women are DHEAS, DHEA, androstenedione, testosterone, and DHT, in downward order of serum concentrations. An initial evaluation includes at least a measurement of testosterone level before beginning the therapy. The oral contraceptives pills are one of the mainstays of therapy. The patients with LOCAH are treated with antiandrogen therapy and most of them respond well to the therapy. Temporary methods of hair removal should be done along with the antiandrogen therapy.

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