The juxtaposition of Leydig cells and the seminiferous epithelium has efficient implication for reproduction. Andropause may be defined as the decrease in function of male reproductive organs that occurs with aging. The diagnosis of androgen deficit is recommended by clinical features and is confirmed by biochemistry. Androgen deficiency must be measured in the perspective of severe systemic illness and certain drug exposures. The decline in testosterone with aging constitutes a true androgen deficiency state important of replacement of therapy is contentious. Hypothalamic-pituitary-testicular (HPT) axis change and associated between changes of aging and androgen levels. The diagnosis of late-onset hypogonadism is a controversial area that has been the focus of position statements from several bodies. Anticoagulant therapy, more commonly prescribed in older men, is a contraindication to intramuscular therapy. the limited data that support extensive benefits of testosterone treatment for older men with low-normal testosterone levels and identified the need for corresponding research programs to better define the amount of its potential benefits as a therapeutic agent used to concentrate on specific problems.