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Chapter-088 Male Contraception

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Kumar KM Prasanna
2. Gundgurthi Abhay
ISBN
9789351526476
DOI
10.5005/jp/books/12535_107
Edition
2/e
Publishing Year
2015
Pages
7
Author Affiliations
1. MS Ramaiah Medical College and Hospital, Bengaluru, Karnataka, India, Bangalore Diabetes Hospital, Bengaluru, Karnataka, India, Bangalore Diabetes Hospital—CDEC, Bengaluru, Karnataka, India, Bangalore Diabetes Hospital and CDEC, Bengaluru, Karnataka, India
2. HCG and Bangalore Institute of Oncology, Sagar Hospital, Bhagwan Mahaveer Jain Hospital, Bengaluru, Karnataka, India
Chapter keywords
Spermatogenesis, male hormonal contraception, Bromodomain, Androgen, Triptolide, Indenopyridines

Abstract

Contraception is an artificial method to prevent pregnancy as a consequence of sexual intercourse. There are four stages of normal spermatogenesis are regulated by hormones. Male contraception can be classified into barrier method, surgical intervention, male hormonal contraception and nonhormonal male contraception. Some surgical methods Vasectomy and Vasal Occlusion are described. The basic principles of MHC are Suppression of gonadotropins, Depletion of iT and cessation of spermatogenesis and Exogenous testosterone to maintain androgenicity. There are some drawbacks of male hormonal contraception are Androgen deprivation features, Androgen excess features, inadequate spermatogenic suppression etc. There are three main targets for non hormonal male contraception is testis, epididymis and the sperm itself. Triptolide, Indenopyridines and Gossypol show inhibitory effects on sperm motility. Nonhormonal male contraception are Bromodomain BRDT inhibitor, JQ1, epididymal protease inhibitor reduced sperm motility and decreased testicular volume.

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