Chapter-090c Turner Syndrome

BOOK TITLE: ESI Manual of Clinical Endocrinology

1. Bajpai Anurag
Publishing Year
Author Affiliations
1. Royal Children’s Hospital Flemington Road, Parkville, Victoria, Melbourne, AIIMS, New Delhi, India, Regency Hospital Limited, Kanpur, Uttar Pradesh, India, Regency Hospital Limited, Kanpur, Uttar Pradesh, India, Fortis CDOC, Fortis Memorial, Research Institute, Gurgaon, Haryana, India, Regency Hospital Limited, A2 Sarvodaya Nagar, Kanpur; Fortis CDOC, B16 Chirag Enclave, New Delhi, India; Fortis Memorial Research Institute Gurgaon, Haryana, India, Royal Children’s Hospital, Melbourne, Australia, Center for Hormone Research, Royal Children’s Hospital, Victoria, Australia, 3052
Chapter keywords
Turner syndrome, karyotype–phenotype correlation, growth hormone, estrogen replacement therapy, ovarian dysfunction


Turner syndrome haploinsufficiency of whole or part of X chromosome associated with growth failure, pubertal delay and cardiovascular anomalies. Clinical features associated with antenatal, infancy, childhood and adolescence are discussed. The syndrome can be diagnosed by prenatal karyotype, karyotype–phenotype correlation and detection of Y Line. Turner syndrome is associated with a constellation of abnormalities affecting multiple body systems such as growth failure, ovarian dysfunction, cardiovascular association, urologocial abnormalities, ophthalmological, hearing loss, dental, skeletal, dermatological and autoimmune associations. To increase adult height in turner syndrome by increasing the growth rate by growth hormone associated with dose, follow up, growth benefit, factors, nonauxological benefits, adverse effects and androgen. Estrogen replacement therapy increase in adult height was offset by psychosocial problems of delayed pubertal maturation. Reproductive issues such as prepregnancy assessment, artificial reproductive techniques and pregnancy care. In addition cardiovascular system, hearing and Indian perspectives are also discussed.

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