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Chapter-097 Adipose Cell Biology

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Phadke Uday K
ISBN
9789351526476
DOI
10.5005/jp/books/12535_122
Edition
2/e
Publishing Year
2015
Pages
8
Author Affiliations
1. Ruby Hall Clinic and Instride, Pune, Maharashtra, India
Chapter keywords
Obesity, adipose tissue, fibrosis, adipocytes, hyperinsulinemia, endotrophin, epicardial fat pad, resistin

Abstract

The excess adipose tissue that results from positive energy balance which causes obesity and it is the most common metabolic disorder in the world. The understanding of origin and development of adipocytes and adipose tissue will be critical to the analysis and treatment of metabolic diseases. Adipose tissue is a remarkably complex organ with profound effects on physiology and pathophysiology, but it has not always been viewed in this light. All eukaryotes from yeast to man are able to store calories in the form of fat, but only vertebrates have specialized cells recognized as adipocytes. The physiological activators of thermogenesis in brown/beige cells are explained in this chapter. The detailed description of adipose tissues and its developmental pattern, plasticity and its behavior in obesity are covered in this chapter. The complexity of the adipose tissue presents several opportunities for studying physiological processes and logically for developing therapeutic interventions.

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