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Chapter-099 Etiopathogenesis of Obesity Including Secondary Causes: Both Endocrine and Genetic Syndromes

BOOK TITLE: ESI Manual of Clinical Endocrinology

Author
1. Chowdhury Subhankar
2. Goswami Soumik
ISBN
9789351526476
DOI
10.5005/jp/books/12535_124
Edition
2/e
Publishing Year
2015
Pages
7
Author Affiliations
1. Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India, IPGME & R and SSKM Hospital, Kolkata, West Bengal, India, IPGME and R, Kolkata, West Bengal, India, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India, Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
2. NRS Medical College and Hospital, Kolkata, West Bengal, India, Nilratan Sircar Medical College, Kolkata, West Bengal, India, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India, NRS Medical College, Kolkata, West Bengal, India, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India
Chapter keywords
Hypothalamic arcuate nucleus, Ghrelin, pancreatic polypeptide, adipokines, cholecystokinin, Genetic Obesity Syndrome

Abstract

The discovery of leptin by Friedman and colleagues in 1994 brought a paradigm shift in our understanding of the problem and paved the way for furious hormonal research in this area opening up several novel vistas. The etiopathologic understanding of obesity assumes importance as it forms the bedrock on which present and future pharmacotherapeutics are based. Ghrelin is the only known circulating orexigen and was discovered as an endogenous ligand for the growth hormone secretagogue receptor. Pancreatic polypeptide is produced largely in the pancreas and inhibits appetite after being released in response to a meal. The genetics, infection, food intake, psychological factors etc are explained in detail. Prader–Willi Syndrome (PWS) is the commonest human genetic obesity Syndrome and arises from lack of expression of genes in the chromosome. The hectic research is going on in the field of obesity that may shed light on undiscovered pathways and further strengthen our stand in the war against obesity.

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