Neck swellings are the most common manifestation of a disease associated the organ. Swellings in the neck are of two types — midline or lateral swellings. While Midline swellings of the neck are associated with diseases such as Ludwig’s angina, sublingual dermoid and lipoma in the submental region and thyroglossal cyst and subhyoid bursitis, the Lateral swellings may be divided in the regions such as submandibular triangle, carotid triangle, posterior triangle. The most common cause of swellings in the neck is enlarged lymph nodes. The lymph nodes are painful in both acute and chronic lymphadenitis. However, they are painless in lymphoma and metastatic lymphadenopathy. A swelling in the submandibular triangle presenting with pain during meals is due to calculous causing obstruction of the duct of the submandibular gland. It is essential to examine the drainage area when examining a patient with enlarged lymph nodes. The left supraclavicular lymph node, when enlarged is called Virchow’s node. When this lymph node is enlarged, the examiner should examine the arm, breast and chest, abdomen as well as the testis for a malignancy. The chapter, in this regard, suggests laboratory tests such as hemogram, tuberculin test and endoscopy.