This chapter discusses the most common transposition flaps, including the rhombic flap, the nasolabial transposition flap, the bilobed flap, and the Z-plasty, the variations of these flaps, and their clinical applications. Transposition flaps represent an essential tool in the armamentarium of facial reconstructive surgeons. Conceptually more complex in design than advancement and rotation flaps, which move tissue across along an uninterrupted tissue plane, transposition flaps move tissue over intervening uninvolved skin. In addition, transposition flaps allow for complete redirection of tension vectors, which is particularly critical for defects near free margins including the eyelid, alar rim, and lip. 24 surgical images are also presented in this chapter.